Key result
High-frequency early diastolic murmurs in children frequently occur alongside completely normal cardiac structure and hemodynamics.
Why the study?
Diastolic murmurs have traditionally been considered abnormal, but their presence in apparently normal children has not been well characterized.
Can apparently normal children present with innocent diastolic murmurs?
Case Report (n=9)
Can apparently normal children present with innocent diastolic murmurs?
This report challenges the traditional teaching that all diastolic murmurs are pathologic by documenting innocent left ventricular diastolic murmurs in normal children.
Answers are grounded in this paper and cite their sources.
May indicate innocent diastolic murmurs in normal children; hypothesis-generating and should not yet change practice.
Diastolic murmurs have always been considered abnormal, but this report presents nine apparently normal children with high-frequency, early, diamond-shaped diastolic murmurs confirmed by intracavitary phonocardiography to arise within the left ventricle. Each child (aged 5 to 15 years) was referred for evaluation of a systolic murmur at the lower left sternal border, but an additional finding at the initial examination was a grade I to III/VI high-pitched diastolic murmur, thought to be decrescendo, at the third and fourth intercostal space at the left sternal edge. The murmurs were best heard when the patient was supine. Cardiac x-rays, including four views with barium, were all clearly normal, as were eight of the nine electrocardiograms and the Frank and McFee vectorcardiograms. Multiple parameters of right and left heart catheterizations were normal in all.
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Liebman et al. (1968) conducted a case report in Diastolic murmurs in apparently normal children (n=9). High-frequency, early, diamond-shaped diastolic murmurs was evaluated on Cardiac abnormalities on x-rays, electrocardiograms, vectorcardiograms, and heart catheterizations. Nine apparently normal children with high-frequency, early diastolic murmurs had normal cardiac x-rays, vectorcardiograms, and right and left heart catheterizations.
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