A Pilot Study Evaluating the Effect of Cooler Dialysate Temperature on Hemodynamic Stability During Prolonged Intermittent Renal Replacement Therapy in Acute Kidney Injury*

Fahad Edrees; Sreelatha Katari; Jack Baty; Anitha Vijayan

doi:10.1097/ccm.0000000000003508

November 1, 2018Critical Care Medicine

A Pilot Study Evaluating the Effect of Cooler Dialysate Temperature on Hemodynamic Stability During Prolonged Intermittent Renal Replacement Therapy in Acute Kidney Injury*

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Key Points

To assess whether lowering dialysate temperature improves hemodynamic stability in critically ill patients with acute kidney injury undergoing prolonged intermittent renal replacement therapy.
Single-center, prospective, randomized, cross-over pilot study conducted in ICUs and a step-down unit at a tertiary referral center.
Enrolled 21 patients with acute kidney injury who underwent a total of 78 prolonged intermittent renal replacement therapy sessions (39 in each arm).
Participants were randomized to receive therapy with dialysate temperature set at 35°C versus 37°C.
Hypotensive events were significantly higher with 37°C dialysate compared to 35°C dialysate (1.49 ± 1.12 vs 0.72 ± 0.69; incidence rate ratio, 2.06; p ≤ 0.0001).
Sessions utilizing cooler dialysate (35°C) demonstrated a higher likelihood of achieving prescribed ultrafiltration targets.

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Implication

Reveals cooler dialysate reduces hypotensive events during prolonged intermittent renal replacement therapy in acute kidney injury, improving fluid removal goals.

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Edrees et al. (2018) studied this question.

synapsesocial.com/papers/6ab72d1c6627b6e9d68fb7b7 https://doi.org/10.1097/ccm.0000000000003508

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A Pilot Study Evaluating the Effect of Cooler Dialysate Temperature on Hemodynamic Stability During Prolonged Intermittent Renal Replacement Therapy in Acute Kidney Injury*

Key Points

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Implication

Discussion

Cite This Study

A Pilot Study Evaluating the Effect of Cooler Dialysate Temperature on Hemodynamic Stability During Prolonged Intermittent Renal Replacement Therapy in Acute Kidney Injury*

Key Points

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Implication

Discussion

Cite This Study

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