Key result
Chemotherapy and disease stage were the only significant prognostic factors for survival in pediatric osteosarcoma, with the overall cohort demonstrating a survival rate of 48%.
Why the study?
What are the survival rates and prognostic factors for children and adolescents with osteosarcoma?
Cohort (n=74)
What are the survival rates and prognostic factors for children and adolescents with osteosarcoma?
In a 35-year retrospective study in Slovenia, pediatric osteosarcoma had a 48% overall survival rate, which was significantly influenced by disease stage and chemotherapy.
Stage and chemotherapy guide osteosarcoma prognosis in this cohort; leaves open validation in contemporary multimodal regimens.
The purpose of this study was to review all the children and adolescents treated for osteosarcoma in Slovenia between 1968 and 1997. Seventy-four patients were included in this retrospective study and classified according to the newly devised classification based on clinical and imaging studies. The overall survival rate is 48%. The stage of the disease and the treatment, including chemotherapy, are the only prognostic factors significantly influencing survival. The survival of patients with osteosarcoma has improved with chemotherapy, but new therapeutic strategies should be found for different stages of disease. The authors' newly devised classification based on clinical and imaging studies proved to be adequate.
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Kuhelj et al. (2005) conducted a cohort in Pediatric osteosarcoma (n=74). Chemotherapy was evaluated on Overall survival. Chemotherapy and disease stage were the only significant prognostic factors for survival in pediatric osteosarcoma, with the overall cohort demonstrating a survival rate of 48%.
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