Key result
A scalp lesion initially misdiagnosed as malignant melanoma was revealed to be a cutaneous angiosarcoma with epithelioid features after further immunohistochemical stains and excisional biopsy.
Case Report (n=1)
Epithelioid angiosarcoma can clinically simulate melanoma, highlighting the importance of immunohistochemical stains and adequate biopsy for accurate diagnosis.
Alerts clinicians to biopsy atypical scalp lesions; leaves open optimal management strategies for epithelioid angiosarcoma.
Angiosarcoma is a rare and highly malignant neoplasm that commonly affects previously irradiated areas and areas of chronic lymphedema, classically presenting in the face and scalp. Angiosarcoma is estimated to have an incidence of .5 per 1,000,000 people in the United States, comprising fewer than 1% of all sarcomas. Epithelioid angiosarcoma is a rare, aggressive subtype that carries a poor prognosis and high mortality rate. Here, we present a case in which a lesion on the scalp was initially misdiagnosed as a malignant melanoma, but after further immunohistochemical stains and a wider excisional biopsy, a cutaneous angiosarcoma with epithelioid features simulating melanoma was revealed.
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Cockerell et al. (2022) conducted a case report in Cutaneous angiosarcoma (n=1). A scalp lesion initially misdiagnosed as malignant melanoma was revealed to be a cutaneous angiosarcoma with epithelioid features after further immunohistochemical stains and excisional biopsy.
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