A comprehensive literature review of hemofiltration (HFT) and subsequent application to cardiopulmonary bypass is discussed. Any existing hypervolemic situation is an indication for HFT. No contraindications for HFT are known when used in conjunction with bypass. A detailed methodology as well as practical guidelines are presented. Specific details associated with HFT have been addressed including choice of diafilter, ultrafiltrate composition, hemoconcentration, hemolysis and other blood damage, acid-base effects, heparin clearance, loss of proteins and amino acids, acidemia, and rebound hyperkalemia.
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Holt et al. (1982) studied this question.
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