Littoral-Cell Angioma as a Cause of Splenomegaly

To the Editor: Littoral-cell angioma is a rare primary tumor of the spleen.1 Considered a benign condition, littoral-cell angioma arises from the normal littoral cells lining the sinus channels of the splenic red pulp. A 59-year-old woman with a six-month history of fatigue, low-grade fever, weight loss, sweats, and diffuse abdominal pain was admitted for an elective splenectomy. Physical examination revealed a palpable spleen. All laboratory tests were normal. An enhanced computed tomographic scan of the abdomen disclosed an enlarged spleen with multiple scattered low-attenuation nodular masses (Figure 1). The 430-g resected spleen (16 by 13 by 7 cm) had . . .