Kidney Transplantation in a Patient with MELAS: A Case Report and Review of the Literature on Medication Use

MELAS (Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke like episodes) is an inherited mitochondrial disorder that can have renal manifestations.These manifestations can consist of proteinuria, glomerular injury or focal or global glomerulosclerosis on biopsy.Ongoing renal injury can result in end stage kidney disease and need for kidney transplantation.Kidney transplantation in MELAS patients is not well described and medication management can be difficult.We describe a recent successful case of kidney transplantation in a patient with MELAS and review the available literature for management in the peri and post-operative setting.