Key result
The vagus nerve plays a crucial role in gut-brain communication, and novel interventions targeting it offer potential treatments for obesity, gastrointestinal, and depressive disorders.
This review provides insights into the vagus nerve's role in the gut-brain axis and the potential of vagus nerve stimulation for treating metabolic and psychiatric disorders.
Hypothesis-generating for vagus-targeted therapies in obesity and mood disorders; leaves open confirmation in randomized trials.
The vagus nerve, as an important component of the gut-brain axis, plays a crucial role in the communication between the gut and brain. It influences food intake, fat metabolism, and emotion by regulating the gut-brain axis, which is closely associated with the development of gastrointestinal, psychiatric, and metabolism-related disorders. In recent years, significant progress has been made in understanding the vagus-mediated regulatory pathway, highlighting its profound implications in the development of many diseases. Here, we summarize the latest advancements in vagus-mediated gut-brain pathways and the novel interventions targeting the vagus nerve. This will provide valuable insights for future research on treatment of obesity and gastrointestinal and depressive disorders based on vagus nerve stimulation.
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Wang et al. (2024) conducted a review in Gastrointestinal, psychiatric, and metabolism-related disorders. Vagus nerve stimulation and targeted interventions was evaluated. The vagus nerve plays a crucial role in gut-brain communication, and novel interventions targeting it offer potential treatments for obesity, gastrointestinal, and depressive disorders.
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