Key result
Pax3, Pax7, and MyoD show broad expression in adult duck heart and non-skeletal tissues.
Why the study?
The relationships between Pax3, Pax7, and MyoD expression in tissues other than skeletal muscle in ducks were unclear.
Hypothesis-generating in avian models; leaves open functional roles in adult heart and non-muscle tissues.
Paired box (Pax) proteins 3 and 7, which are two members of the PAX gene family, are important to animal skeletal muscle development acting their roles by mediating the expression of MyoD. These three genes expressed in several of tissues and organs in vertebrates. In order to investigate whether or not the relationships between Pax3, Pax7 and MyoD in other tissues are still similar with that in skeletal muscle, we detected the expression of Pax3, Pax7 and MyoD in duck different tissues and organs using real-time PCR technical. Results showed that these three genes not only expressed in skeletal muscle tissues, but also expressed in other tissues like heart, brain, spleen, fat and so on. The Pax3 and Pax7 also have coordinate roles in heart, spleen and brain, which are similar with that in skeletal muscle. Results indicate that the MyoD, Pax3 and Pax7 may involve in other tissues development besides skeletal muscle in duck and may also act on a similar mechanism between Pax3/7 and MyoD in skeletal muscle.
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Chen et al. (2012) studied this question. Tissue-specific expression of Pax3, Pax7, and MyoD was evaluated on Gene expression in different tissues and organs. Pax3, Pax7, and MyoD are expressed in multiple adult duck tissues including heart, brain, spleen, and fat, suggesting they may be involved in the development of tissues other than skeletal muscle.
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