Key result
A rare case of primary synovial sarcoma arising in the fallopian tube, confirmed by SYT-SSX1 fusion gene transcript, partially responded to paclitaxel and carboplatin after recurrence.
Case Report (n=1)
This case demonstrates that synovial sarcoma can rarely arise in the fallopian tube and may respond to paclitaxel and carboplatin upon recurrence.
Should not guide chemotherapy choices for gynecologic sarcomas; leaves open the spectrum of synovial sarcoma sites and responses.
Synovial sarcoma, a malignant mesenchymal neoplasm, occurs mostly near the joints of the extremities and occasionally outside the joint such as lung. We report a case of soft tissue sarcoma arising in the fallopian tube origin that showed characteristic pathological appearance of biphasic synovial sarcoma. Molecular analysis detected a fusion gene transcript of synovial sarcoma translocation (SYT) gene from chromosome 18 and synovial sarcoma X chromosome breakpoint 1 (SSX1) gene, which is believed to pathognomonic for synovial sarcoma of joint origin. Recurrent abdominal tumor, observed at 12 month after the initial surgery and following chemotherapy using doxorubicin, cisplatin and ifosfamide, partially responded to chemotherapy using paclitaxel and carboplatin and, then, optimal surgery was performed. This is the first report of a synovial sarcoma arising in the fallopian tube.
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Mitsuhashi et al. (2006) conducted a case report in Primary Synovial Sarcoma in Fallopian Tube (n=1). Surgery and chemotherapy was evaluated on Tumor response and recurrence. A rare case of primary synovial sarcoma arising in the fallopian tube, confirmed by SYT-SSX1 fusion gene transcript, partially responded to paclitaxel and carboplatin after recurrence.
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