Key result
Tl-201 perfusion scanning improves CAD detection sensitivity to ~75% over exercise ECG alone.
Why the study?
Rest and exercise ECGs have suboptimal sensitivity and specificity for detecting coronary heart disease, motivating evaluation of thallous chloride Tl 201 myocardial perfusion scanning.
Does myocardial perfusion scanning using thallous chloride Tl 201 improve the detection of coronary heart disease compared to exercise electrocardiography alone in patients with chest discomfort syndrome?
Cross-Sectional (n=95)
Does myocardial perfusion scanning using thallous chloride Tl 201 improve the detection of coronary heart disease compared to exercise electrocardiography alone in patients with chest discomfort syndrome?
Rest and stress myocardial perfusion scanning with thallous chloride Tl 201 provides improved sensitivity with good specificity in the diagnosis of coronary heart disease compared with exercise electrocardiography alone.
Rest and exercise ECGs are the most widely used "noninvasive" tests for detecting coronary heart disease, but their sensitivity and specificity are suboptimal. Therefore, the diagnostic value of myocardial perfusion scanning using thallous chloride Tl 201 during rest and stress electrocardiography was examined in 95 patients with a chest discomfort syndrome. Overall, thallous chloride Tl 201 perfusion scanning had a sensitivity of 75% and a specificity of 91% for coronary heart disease compared with 56% sensitivity and 86% specificity with exercise-induced ST segment depression on the ECG. Combining rest and stress ECGs resulted in a sensitivity of 71%. In patients with coronary heart disease, perfusion scanning had a sensitivity of 93% for asynergy compared with 58% for exercise-induced ECG ST depression. Rest and stress myocardial perfusion scanning with thallous chloride Tl 201 provides improved sensitivity with good specificity in the diagnosis of coronary heart disease compared with exercise electrocardiography alone.
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Monte Bodenheimer (1979) conducted a cross-sectional in Coronary heart disease (n=95). Thallous chloride Tl 201 myocardial perfusion scanning vs. Exercise electrocardiography was evaluated on Sensitivity for coronary heart disease. Thallous chloride Tl 201 myocardial perfusion scanning provided 75% sensitivity and 91% specificity for coronary heart disease, compared with 56% and 86% for exercise electrocardiography alone.
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