Key result
PCOS is linked to elevated visfatin levels that correlate positively with atherogenic lipids.
Why the study?
The detailed role of visfatin on lipoprotein lipid profiles in women with PCOS undergoing ovarian stimulation remains unclear and requires further investigation.
Are visfatin levels correlated with atherogenic lipid profiles in women with PCOS?
Case-Control (n=160)
Are visfatin levels correlated with atherogenic lipid profiles in women with PCOS?
Visfatin levels are elevated in women with PCOS and correlate with an atherogenic lipid profile, suggesting a potential link to cardiovascular risk in this population.
Elevated visfatin should not yet change PCOS management; leaves open its value as biomarker or target for prospective validation.
The aim of this study was to determine serum and follicular fluid (FF) visfatin levels in age and weight-matched women with polycystic ovary syndrome (PCOS) and normally ovulating subjects undergoing controlled ovarian stimulation and correlate them with their lipid and lipoprotein levels. We included 80 PCOS women (40 lean and 40 overweight) and 80 age- and weight-matched controls, enrolled in the IVF program. In PCOS women, we determined significantly increased serum and FF visfatin as well as serum levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, apolipoprotein B, lipoprotein(a) and homocysteine, while high-density lipoprotein cholesterol and apolipoprotein A1 were significantly lower compared to controls. Serum visfatin levels positively correlated with total cholesterol, LDL cholesterol, triglycerides, lipoprotein(a) and homocysteine levels and negatively with apolipoprotein A1. FF visfatin levels positively correlated with triglycerides and homocysteine and negatively with apolipoprotein A1. Dyslipidemia is common in reproductive age women with PCOS exposing them to risk for cardiovascular diseases. However, the detailed role of visfatin on lipoprotein lipid profile awaits further clarification through future investigation.
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Tsouma et al. (2014) conducted a case-control in Polycystic ovary syndrome (n=160). Polycystic ovary syndrome vs. Normally ovulating age- and weight-matched controls was evaluated on Serum and follicular fluid visfatin levels and correlation with lipid and lipoprotein levels. Polycystic ovary syndrome was associated with significantly increased serum and follicular fluid visfatin levels that positively correlated with atherogenic lipids compared to matched controls.
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