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June 28, 2006Synthesis

Synthesis and Characterization of Some Novel 2-(Trifluoromethyl)pyrimido[1,2-a]benzimidazoles and Pyrimido[1,2-a]benzimidazol-2H)-ones of Biological Interest

Nilo Zanatta Aurea Echevarrı́a Simone S. Amaral Andressa Esteves-Souza Patrícia Bulegon Brondani Darlene C. Flores Hélio G. Bonacorso Alex F. C. Flores Marcos A. P. Martins

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Abstract

The synthesis of some potentially active 2-(trifluoromethyl)pyrimido[1,2-a]benzimidazoles and pyrimido[1,2-a]benzimidazol-2(1H)-ones by the cyclization of 4-alkoxyvinyl trifluoro(chloro)methyl ketones with 2-aminobenzimidazole is described. The structure of the products was assigned based on 1H and 13C NMR as well as 2D-NMR experiments. Some of the obtained products exhibited significant DNA-topoisomerase I inhibitory activity.

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Zanatta et al. (2006) studied this question.

synapsesocial.com/papers/6ab756421b6e853d2aad8034 https://doi.org/10.1055/s-2006-942444

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