2-Chloro-1-methoxymethylindole-3-carboxaldehyde: Introduction of Nucleophiles into the Indole 2-Position and an Approach to the Unusual TrpHis Fragment of Moroidin

All articles of this category 2-Chloro-1-methoxymethylindole-3-carboxaldehyde ( 3 ) is an excellent substrate for a range of nitrogen nucleophiles and gives 2-substituted indoles. Use of a histidine based nucleophile results in the formation of the N -(2-indolyl)imidazole ( 11 ), a precursor for the unusually substituted tryptophan residue of the bicyclic octapeptide moroidin.