Key result
MMP-1 2G homozygosity is linked to ~50% lower coronary heart disease risk vs 1G.
Why the study?
Matrix metalloproteinase-1 gene expression may influence the development and progression of atherosclerotic plaques, but its association with coronary heart disease risk in humans was unclear.
Does the 1G/2G polymorphism in the MMP-1 gene or the 5A/6A polymorphism in the MMP-3 gene affect the risk of coronary heart disease in older Caucasian adults?
Population
471 Caucasian men and women aged 66-75 years from Sheffield, UK
Comparison
Homozygous 2G allele vs homozygous 1G allele of MMP-1 gene; also 5A/6A polymorphism in MMP-3 gene
Design
Observational genotyping study
Authors
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MMP-1 2G homozygosity may associate with lower CHD risk in older adults; leaves open whether this extends mouse plaque-protection data or informs risk stratification.
Observational (n=471)
No
Does the 1G/2G polymorphism in the MMP-1 gene or the 5A/6A polymorphism in the MMP-3 gene affect the risk of coronary heart disease in older Caucasian adults?
Odds Ratio: 0.5 (95% CI 0.3–0.9)
The 2G allele of the MMP-1 gene is associated with a reduced risk of coronary heart disease, suggesting a genetic role in human atherogenesis.
Shu Ye (2003) conducted an observational in coronary heart disease (n=471). Homozygous 2G allele of the MMP-1 gene vs. Homozygous 1G allele of the MMP-1 gene was evaluated on coronary heart disease (OR 0.5, 95% CI 0.3 to 0.9). Being homozygous for the 2G allele of the MMP-1 gene was associated with a reduced risk of coronary heart disease compared to the 1G allele (OR 0.5; 95% CI 0.3-0.9).
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