Outcome of Intrauterine Injection of Human Chorionic Gonadotropin before Embryo Transfer in Patients with Previous Ivf/Icsi Failure: A Randomized Study

Aim To evaluate the effect of intrauterine injection of 500 IU hCG before embryo transfer in patients with previous ICSI failure. Background The implantation process is the most important part of pregnancy, a lot of factors are responsible for implantation, it is well known that majority of pregnancies are lost during the implantation phase and often is undetected. It is known that hCG has an important function in angiogenesis and reduces the inflammatory response which in turn favor the implantation process. hCG is secreted early during the pregnancy, hence plays an important role. Methods A prospective randomized study was conducted in Radhakrishna Multispecialty Hospital and IVF Centre, Bengaluru, India. Total patients for ICSI cycle was 83(n). Out of which 32 patients were recruited in this study. The study group (n = 16) received intrauterine administration of 500 IU hCG before ET. The control group (n = 16) underwent ET without hCG. Results In both the groups, the mean age of the patients was around 29, the estradiol level mean was around 2569 ± 895 and in control group around 2467 ± 906. It was noted that fertilization rate in test group was around 88% and in control group around 75% hence showing that injection hCG proved its beneficial. It was noted that maximum embryos was from nondonor in test group, donor fresh embryos were around 3. Conclusion The intrauterine injection of 500 IU hCG before embryo transfer statistically improved the implantation rates and pregnancy rates with good outcome. How to cite this article Bhat VV, Dutta I, Dutta DK, Gcitha MD. Outcome of Intrauterine Injection of Human Chorionic Gonadotropin before Embryo Transfer in Patients with Previous Ivf /Icsi Failure: A Randomized Study. J South Asian Feder Obst Gynae 2014;6(1):15-17.