Key result
Review links DIS3L2 and XRN1 exoribonuclease loss to distinct disease pathways.
Why the study?
The specific roles of the exoribonucleases DIS3L2 and XRN1 in the development of multicellular organisms and human disease are not well understood.
This review summarizes the roles of exoribonucleases DIS3L2 and XRN1 in the pathogenesis of human disease and their associated cellular pathways.
Roles of DIS3L2 and XRN1 in development and disease remain understudied; leaves open their relevance to human pathology and therapeutic targeting.
RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is known about their specific roles in the development of multicellular organisms or human disease. This review focusses on the roles of DIS3L2 and XRN1 in the pathogenesis of human disease, particularly in relation to phenotypes seen in model organisms. The known diseases associated with loss of activity of DIS3L2 and XRN1 are discussed, together with possible mechanisms and cellular pathways leading to these disease conditions.
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Pashler et al. (2016) conducted a review in Diseases associated with loss of activity of DIS3L2 and XRN1. DIS3L2 and XRN1 was evaluated. This review summarizes the known diseases associated with loss of activity of the exoribonucleases DIS3L2 and XRN1, along with possible mechanisms and cellular pathways leading to these conditions.
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