Why the study?
Circulating biomarkers of inflammation may not adequately reflect coronary artery inflammatory activity at the individual patient level, limiting cardiovascular risk prediction.
Highlights the role of imaging coronary inflammation, specifically epicardial and perivascular adipose tissue, for cardiovascular risk prediction.
Supports adipose tissue imaging for risk prediction; leaves open prospective validation before clinical adoption.
Inflammation plays an important part in the development of atherosclerosis and is a predictor of cardiovascular disease manifestation.1 Although circulating biomarkers of inflammation—eg, high sensitivity C-reactive protein—are associated with cardiovascular risk, they might not adequately reflect inflammatory activity in the coronary arteries at the individual patient level. Epicardial and perivascular adipose tissue—surrounding the heart and coronary arteries—secretes proinflammatory and anti-inflammatory cytokines and chemokines locally, and these tissues are associated with the extent and progression of coronary atherosclerosis and hard coronary events.
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Mahabadi et al. (2018) conducted a review in Coronary atherosclerosis. Imaging of coronary inflammation was evaluated.
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