1,2‐benzisothiazolin‐3‐one (BIT), at growth inhibitory concentrations, has little effect on membrane integrity but significantly inhibits the active transport and oxidation of glucose by washed Staphylococcus aureus cells. The dependancy of these metabolic processes on thiol‐containing enzymes and the observed interaction of BIT with glutathione and isolated enzyme preparations suggests that cellular thiol groups are a major target for BIT.
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Fuller et al. (1985) studied this question.
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