The porcine sarcolipin (SLN) gene: identification of an SNP and linkage mapping to chromosome 9

Sarcolipin (SLN) is a 31-amino acid prote olipid that regulates the activity of SERCA1 (ATP2A1), a fast-twitch skeletal muscle sarcoplasmic reticulum Ca2+-ATPase. A 324 bp expressed sequence tag was isolated from a porcine skeletal muscle cDNA library (EMBL accession number Z98820). Two alleles were identified by SSCP analysis in the 218 bp fragment of the porcine SLN gene. Mendelian segregation was confirmed in three-generation families of the PiGMaP Consortium. Linkage mapping assigned this gene to porcine chromosome 9.