Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients

Supharat Suvichapanich; Sukanya Wattanapokayakit; Taisei Mushiroda; Hideki Yanai; Charoen Chuchottawon; Tassawan Kantima; Supalert Nedsuwan; Wimon Suwankesawong; Cholticha Sonsupap; Roongkarn Pannarunothai; Sukanya Tumpattanakul; Warawut Bamrungram; Achara Chaiwong; Surakameth Mahasirimongkol; Sasithorn Mameechai; Weerapat Panthong; Nantawan Klungtes; Amara Munsoo; Udomrat Chauychana; Molrudee Maneerat; Koya Fukunaga; Yosuke Omae; Katsushi Tokunaga

doi:10.1128/aac.02692-18

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Abstract

Antituberculosis drug-induced liver injury (ATDILI) is a common side effect leading to tuberculosis (TB) treatment disruption. The mechanism of the disease remains poorly understood. We conducted a genomewide association study (GWAS) to investigate all possible genetic factors of ATDILI in Thai patients. This study was carried out in Thai TB patients, including 79 ATDILI cases and 239 tolerant controls from our network hospitals in Thailand.

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Suvichapanich et al. (2019) studied this question.

synapsesocial.com/papers/6ab76bac1a7e4c46bba6f0c9 https://doi.org/10.1128/aac.02692-18

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Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients

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Abstract

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Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients

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