Drug release from polyureaurethane coating modified by plasma immersion ion implantation

A crosslinked polyurethanurea (PUU) coating was synthesised from a solution on metal vascular stents. In the model system the glucocorticoid prednisolone was inserted into the film by the equilibrium swelling method; after this plasma immersion ion implantation (PIII) was applied to modify the coating for improved release kinetics. This treatment causes the formation of oxygen-containing and unsaturated carbon-carbon groups in the PUU and a destruction of the drug in the surface layer. As a consequence, the release rate of prednisolone to water becomes more stable with time than it is at the untreated coating. In this drug release system PIII treatment prevents an initial toxically high release of the drug. By this it allows the incorporation of a higher amount of the drug and an extended action.