Key result
Ketosis at PICU admission is linked to increased arteriovenous oxygen saturation differences in ~31% of patients.
Why the study?
Hyperglycemia after cardiac surgery and cardiopulmonary bypass in children is associated with worse outcomes, but causality and benefits of tight glycemic control remain unproven.
Is ketosis after cardiopulmonary bypass in children associated with an inadequate balance between oxygen transport and consumption?
Observational (n=96)
No
Is ketosis after cardiopulmonary bypass in children associated with an inadequate balance between oxygen transport and consumption?
p-value: p=0.05
Ketosis is common after pediatric cardiopulmonary bypass and is associated with an impaired balance between oxygen transport and consumption, which can be corrected by insulin.
Ketosis may signal oxygen supply-demand mismatch after pediatric bypass; leaves open whether correction improves outcomes.
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Klee et al. (2016) conducted an observational in Undergoing cardiac surgery with cardiopulmonary bypass (n=96). Ketosis was evaluated on Increased difference between arterial and venous oxygen saturation (p=0.05). Ketosis at PICU admission was present in 31.2% of patients and was an independent risk factor for an increased difference between arterial and venous oxygen saturation (p=0.05).
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