Answers are grounded in this paper and cite their sources.
We report a family with a new hexokinase variant that gives rise to nonspherocytic hemolytic anemia in one apparently homozygous family member. The variant enzyme has a normal pH optimum, normal reaction kinetics, and normal electrophoretic properties, but has reduced activity and is apparently inactivated rapidly as the affected erythrocytes age.
No takes yet. Share an insight, caveat, or question.
Trueworthy et al. (1978) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: