Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD. Your brain on metals: exposure in C. elegans to metals such as manganese, methylmercury and copper can recapitulate models of neurodegenerative diseases such as Parkinson’s and Alzheimer’s diseases.
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Martinez‐Finley et al. (2011) studied this question.
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