Key result
Alzheimer's and frontotemporal dementia are linked to sympathetic dominance, with additional parasympathetic suppression in Alzheimer's.
Why the study?
Autonomic dysfunction occurs early in central autonomic structures in FTD and AD, and understanding its pattern may aid diagnosis and prognosis.
Does the pattern of autonomic dysfunction differ between patients with Alzheimer's disease and frontotemporal dementia?
Comparison
Patients with AD and FTD vs healthy controls
Design
Case-control study
Authors
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Autonomic testing may aid prognosis in FTD and AD; leaves open pattern differences and sudden-death links.
Case-Control (n=59)
Does the pattern of autonomic dysfunction differ between patients with Alzheimer's disease and frontotemporal dementia?
p-value: p=0.04
Both Alzheimer's disease and frontotemporal dementia are associated with sympathetic dominance, but the additional presence of parasympathetic suppression in Alzheimer's disease may serve as a differentiating biomarker.
Issac et al. (2016) conducted a case-control in Alzheimer's disease and frontotemporal dementia (n=59). Alzheimer's disease and frontotemporal dementia vs. Healthy controls was evaluated on Heart rate variability and conventional cardiac autonomic function (p=0.04). Patients with Alzheimer's disease and frontotemporal dementia showed sympathetic dominance, with Alzheimer's patients additionally exhibiting parasympathetic suppression (P=0.04).
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