Key result
rK39-based ELISA achieves ~98% diagnostic accuracy for Kala-azar, outperforming KAtex in sensitivity.
Why the study?
Evaluation of rK39 based ELISA and KAtex tests for diagnosis of Kala-azar was needed to compare their sensitivity and specificity against the confirmatory rK39 ICT test.
What is the sensitivity and specificity of rK39 based ELISA and KAtex tests for the diagnosis of Kala-azar compared to rK39 ICT?
Cross-Sectional (n=200)
Yes
What is the sensitivity and specificity of rK39 based ELISA and KAtex tests for the diagnosis of Kala-azar compared to rK39 ICT?
Answers are grounded in this paper and cite their sources.
rK39 antigen based ELISA is superior in sensitivity, while KAtex is superior in specificity for the diagnosis of Kala-azar.
This cross sectional study was carried out in SSMC for a period of one year from July 2007 to June 2008 to evaluate rK39 based ELISA and KAtex tests for diagnosis of Kala-azar. Total 150 patients were selected clinically. For this study rK39 ICT was regarded as confirmatory test according to national guideline. Among 150, total 100 cases were confirmed to be positive for Kala-azar by rK39 ICT test. Age and sex matched 25 healthy persons each from endemic and non-endemic area were taken as control. Among the 100 sero confirmed cases KAtex was positive in 87 (sensitivity of 87%) while ELISA was positive in 98 cases (sensitivity 98%). Among the 50 controls none were positive by KAtex test while 1 (one) ELISA test was positive resulting in specificity of these tests 100% and 98% respectively. The result of the study clearly showed superiority of rK39 antigen based ELISA in respect of sensitivity and KAtex in respect of specificity.KYAMC Journal Vol. 6, No.-1, Jul 2015, Page 574-578
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Habib et al. (2017) conducted a cross-sectional in Kala-azar (Visceral Leishmaniasis) (n=200). rK39 based ELISA and KAtex vs. rK39 ICT (confirmatory test) was evaluated on Diagnostic sensitivity and specificity. The rK39-based ELISA demonstrated 98% sensitivity and 98% specificity for diagnosing Kala-azar, whereas the KAtex test showed 87% sensitivity and 100% specificity.
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