New Strategies for Anti-Inflammatory Drug Development

Copyright: © 2012 Akkol EK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Inflammatory diseases are one of the major health problems worldwide. Acute and chronic inflammations are induced by several chemical mediators such as prostaglandins, leukotrienes and platelet-activating factor. Anti-inflammatory agents show their activities through several activity mechanisms [1]. Non-steroid antiinflammatory drugs (NSAIDs) are the most prescribed drugs for treatment of inflammatory diseases. The NSAIDs provide the patients with symptomatic relief, however, they do not modify the pathogenesis of inflammation [2]. Furthermore, prolonged use should be avoided due to severe side effects particularly on gastric mucosa. Therefore, searching for new drug candidates in the treatment of chronic inflammation has great importance.