After the intermittent administration of succinylcholine to 24 ophthalmic patients during halothane anesthesia, 2 certain (immunochemically verified) and 5 probable cases of myoglobinuria were found. In all these patients the serum activity of creatine kinase was also elevated. These findings are interpreted as signs of probable museular injury. It is recommended that intermittent administration of succinylcholine during halothane anesthesia should be abandoned.
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Airaksinen et al. (1966) studied this question.