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, reduces tumor burden, and extends survival in mouse xenograft models. Consistent with its role in maintaining mitotic fidelity, USP15 depletion sensitizes ovarian cancer cells to mitotic inhibitors and DNA damage inducing chemotherapeutics. Collectively, these findings establish USP15 as a key driver of ovarian cancer metastasis and highlight its potential as an actionable therapeutic target to improve the effectiveness of extant chemotherapeutic agents.
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Ogunsanya et al. (2026) studied this question.