Key result
Older age, limb edema, and elevated ESR are linked to advanced lupus nephritis biopsy staging.
Why the study?
There are controversies regarding the diagnosis of lupus nephritis and variability in its clinical manifestations and severity among patients.
Do clinical and laboratory findings correlate with biopsy staging in patients with lupus nephritis?
Observational (n=30)
Do clinical and laboratory findings correlate with biopsy staging in patients with lupus nephritis?
Clinical and laboratory findings such as age, limb edema, and ESR are significantly associated with biopsy staging in lupus nephritis, potentially facilitating early determination of disease severity.
Background: There are controversies regarding the diagnosis of lupus nephritis. Also, its clinical manifestations and severity are different from one patient to another. Objectives: The current study aimed to interpret clinical and laboratory features of lupus nephritis according to the results of the biopsy. Methods: Following a retrospective design, 30 patients with lupus, who were candidates for renal biopsy and undergoing kidney biopsy, were studied. Clinical findings (blood pressure and limb edema) and laboratory findings (Cr, ESR, CRP, BUN, C3, C4, CH50, Anti-ds DNA, and hematuria) were gathered. Finally, the diagnostic value of clinical and laboratory findings was interpreted according to the biopsies and the staging of samples in the pathology. Data were analyzed using SPSS. Quantitative variables are displayed using mean and quartiles. Fisher’s exact test was used to compare study groups. Also, independent samples t-test and Levene’s test were used to evaluate variances of quantitative variables. Results: Of 30 cases, 5 had a biopsy of 3 and FSGN. Also, 8 cases were on stages 3 and 4, 9 had a stage of 4 biopsy, and 8 cases were on stage 4 - 5, 5, and 5 - 6. The association between age, Limp edema, ESR, and biopsy was statistically significant (P < 0.05). Conclusions: This study demonstrated the usefulness of clinical and laboratory findings to determine the severity of the disease in the shortest time, mainly due to its easy, non-invasive access and early preparation of the results, which will facilitate the initiation of treatment.
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Soufivand et al. (2021) conducted an observational in Lupus nephritis (n=30). Clinical and laboratory findings was evaluated on Association between clinical/laboratory findings and biopsy staging (p=< 0.05). Age, limb edema, and ESR were significantly associated with biopsy staging in patients with lupus nephritis (P < 0.05).
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