Key result
Adipose stem cells from women with endometrial cancer showed significantly different IL-8 secretion across adipose depots, with the highest levels in the omental depot (p < 0.0001).
Why the study?
Do inflammatory biomarker levels secreted by adipose stem cells differ across omental, retroperitoneal, and subcutaneous depots in women with endometrial cancer?
Observational (n=22)
Do inflammatory biomarker levels secreted by adipose stem cells differ across omental, retroperitoneal, and subcutaneous depots in women with endometrial cancer?
Inflammatory biomarker expression, particularly IL-8 and VEGFA, varies significantly across different adipose tissue depots in women with endometrial cancer.
Omental adipose stem cells may drive IL-8 inflammation in endometrial cancer; hypothesis-generating and should not yet change practice.
AIM: To explore inflammatory biomarkers secreted by adipose stem cells (ASCs) in omental, retroperitoneal and subcutaneous adipose tissues of women with endometrial cancer. PATIENTS & METHODS: ASCs were collected from 22 women, aged 35-83 years, undergoing hysterectomy for endometrial cancer. Angiopoietin-2, EGF, IL-8, leptin, VEGFA, VEGFC and VEFGD levels in the ASC-conditioned media were analyzed by Luminex. RESULTS: We found a significant difference between the three depots for IL-8 (p < 0.0001), with the highest levels of IL-8 in the omental depot. VEGFA levels were highest in the retroperitoneal depot. CONCLUSION: This is one of the first studies to explore biomarker expression in ASC-conditioned media in adipose tissue. ASC characteristics may be important to evaluate in relation to cancer risk.
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Linkov et al. (2018) conducted an observational in Endometrial cancer (n=22). Adipose tissue depot (omental, retroperitoneal, subcutaneous) vs. Comparison between depots was evaluated on Inflammatory biomarker levels in ASC-conditioned media (p=<0.0001). Adipose stem cells from women with endometrial cancer showed significantly different IL-8 secretion across adipose depots, with the highest levels in the omental depot (p < 0.0001).
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