Blood Products for Spanish Influenza: A Future H5N1 Treatment?

Letters1 May 2007Blood Products for Spanish Influenza: A Future H5N1 Treatment?Susan J. Logtenberg, MD and Henk J. Bilo, MD, PhDSusan J. Logtenberg, MDFrom Isala Clinics, 8025 AB, Zwolle, the Netherlands.Search for more papers by this author and Henk J. Bilo, MD, PhDFrom Isala Clinics, 8025 AB, Zwolle, the Netherlands.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-9-200705010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: We would like to add to the discussion in Luke and colleagues' meta-analysis (1) of historic literature about the possible beneficial effect of transfusion on the clinical outcome of patients with Spanish influenza. We suggest that the effect might not be due to the specific neutralizing effects of anti-influenza antibodies in the blood product but rather to the transfusion of whole blood, including immunoglobulins (and thus the provision of plasma oncotic pressure).We recently reported on a previously healthy man with severe shock who required admission to the intensive care unit. His condition was associated with an ...References1. Luke TC, Kilbane EM, Jackson JL, Hoffman SL. Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? Ann Intern Med. 2006;145:599-609. [PMID: 16940336] LinkGoogle Scholar2. Logtenberg SJ, Pasma FH, Wolfhagen MJ, Dikkeschei LD, Bilo HJ. Disappearance of immunoglobulins in acute phase of influenza A infection. Lancet. 2006;368:1546. [PMID: 17071289] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Isala Clinics, 8025 AB, Zwolle, the Netherlands.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: Convalescent Blood Products for Spanish Influenza Pneumonia: A Future H5N1 Treatment? Thomas C. Luke , Edward M. Kilbane , Jeffrey L. Jackson , and Stephen L. Hoffman Blood Products for Spanish Influenza: A Future H5N1 Treatment? Thomas C. Luke and Stephen L. Hoffman Metrics Cited ByPotential Drugs and Remedies for the Treatment of COVID-19: a Critical ReviewEarly experience with convalescent plasma as immunotherapy for COVID‐19 in China: Knowns and unknownsNew Wisdom to Defy an Old Enemy: Summary from a scientific symposium at the 4th Influenza Vaccines for the World (IVW) 2012 Congress, 11 October, Valencia, Spain 1 May 2007Volume 146, Issue 9Page: 686-687KeywordsBloodBlood plasmaBlood transfusionConflicts of interestForecastingH5N1Influenza A virusIntensive care unitsProteins ePublished: 1 May 2007 Issue Published: 1 May 2007 CopyrightCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...