The antifungal β-lactam (2R, 5S)-2-(hydroxymethyl)clavam was synthesized in a convergent and stereocontrolled manner from methyl 6-phthalimidopenicillanate and 2, 3-O-isopropylidene-(R)-glyceraldehyde. Convenient methods of acetonide cleavage and phthalimide deblocking are also described.
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Konosu et al. (1991) studied this question.