Key result
Inflammatory bowel disease is linked to ~1.6 mg/dL lower ApoC3 levels vs. controls.
Why the study?
Inflammatory bowel disease has been associated with an abnormal lipid profile, and the role of apolipoprotein C-III in IBD and its relationship to disease characteristics is unclear.
Are Apolipoprotein C3 serum levels downregulated in patients with inflammatory bowel disease compared to controls?
Cross-Sectional (n=405)
Are Apolipoprotein C3 serum levels downregulated in patients with inflammatory bowel disease compared to controls?
Mean Difference: -1.6 (95% CI -2.5–-0.7)
p-value: p=0.001
Patients with inflammatory bowel disease have significantly lower serum levels of Apolipoprotein C3 compared to controls, independent of cardiovascular risk factors and statin use.
INTRODUCTION: Inflammatory bowel disease (IBD) has been associated with an abnormal lipid profile. Apolipoprotein C-III (ApoC3) is a key molecule of triglyceride metabolism that is known to be related to inflammation and cardiovascular disease. In this study, we aim to study whether ApoC3 serum levels differ between patients with IBD and controls and whether the hypothetical disturbance of ApoC3 can be explained by IBD characteristics. METHODS: This is a cross-sectional study that included 405 individuals, 197 patients with IBD and 208 age-matched and sex-matched controls. ApoC3 and standard lipid profiles were assessed in patients and controls. A multivariable analysis was performed to analyze whether ApoC3 serum levels were altered in IBD and to study their relationship to IBD characteristics. RESULTS: After fully multivariable analysis including cardiovascular risk factors, use of statins, and changes in lipid profile caused by the disease itself, patients with IBD showed significant lower serum levels of ApoC3 (beta coef. -1.6 [95% confidence interval -2.5 to -0.7] mg/dL, P = 0.001). Despite this, inflammatory markers, disease phenotypes, or disease activity of IBD was not found to be responsible for this downregulation. DISCUSSION: Apolipoprotein C3 is downregulated in patients with IBD.
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Hernández-Camba et al. (2022) conducted a cross-sectional in Inflammatory bowel disease (IBD) (n=405). Inflammatory bowel disease vs. Age-matched and sex-matched controls was evaluated on ApoC3 serum levels (beta coef. -1.6 mg/dL, 95% CI -2.5 to -0.7, p=0.001). Inflammatory bowel disease was associated with significantly lower serum levels of ApoC3 compared to controls (beta coef. -1.6 mg/dL; 95% CI -2.5 to -0.7; P=0.001).
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