Key result
PNPLA3 rs738409 minor allele linked to ~2 mg/dl lower total cholesterol per copy.
Why the study?
Recent genome-wide association studies identified PNPLA3 to be associated with hepatic fat content and liver function, suggesting a possible involvement in hepatic lipoprotein metabolism.
Is the rs738409 variant in the adiponutrin gene associated with altered lipoprotein metabolism in West-Eurasian populations?
Population
23,274 participants from eight independent West-Eurasian study populations
Comparison
Common non-synonymous variant rs738409 minor allele vs major allele in adiponutrin gene
Design
Observational cohort study
Authors
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PNPLA3 rs738409 variant linked to modestly lower LDL cholesterol; leaves open implications for cardiovascular risk.
Observational (n=23,274)
Yes
Is the rs738409 variant in the adiponutrin gene associated with altered lipoprotein metabolism in West-Eurasian populations?
Mean Difference: -2.43
p-value: p=8.87 x 10(-7)
The rs738409 variant in the adiponutrin (PNPLA3) gene is associated with lower levels of total, non-HDL, and LDL cholesterol, suggesting a role in apoB-containing lipoprotein metabolism.
Kollerits et al. (2009) conducted an observational in Lipoprotein metabolism (n=23,274). Adiponutrin (PNPLA3) rs738409 variant vs. Major allele was evaluated on Total cholesterol concentration (MD -2.43 mg/dl, p=8.87 x 10(-7)). Each copy of the minor allele of the PNPLA3 rs738409 variant decreased total cholesterol by 2.43 mg/dl (P=8.87x10^-7), non-HDL by 2.35 mg/dl, and LDL by 1.48 mg/dl.
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