The First Total Synthesis of (R)-(-)-Pyridindolol K2 and Its Enantiomer

The enantioselective first total synthesis of (R)-(-)-pyridindolol K2(2) together with its enantiomer (2a) has been achieved in nine steps.Pyridindolol K2 (2) was isolated from the culture broth of Streptomyces sp.K93-0711 together with pyridindolol K1 (1) and pyridindolol (3) in 1997 by Omura and co-workers. 1 Pyridindolol (3) is already known to be a β-galactosidase inhibitor, 2 and pyridindolol glucosides have also been isolated from