Four new polyoxygenated steroids (4–7) containing a spiroketal function have been isolated from the gorgonian Isis hippuris. Their structures were determined by spectral correlation and by interconversion. Previously assigned configuration at the C-22 of hippurin-1 (3) was reversed by spectroscopic evidence. Two (4, 7) of the steroids exhibited potent in vitro anticancer activities.
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Higa et al. (1981) studied this question.
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