Key result
In patients undergoing peritoneal dialysis, higher relative overhydration (RelOH) was significantly correlated with lower executive function, including fewer categories achieved (r=-0.32, p=0.02).
Why the study?
Does dialysis adequacy correlate with cognitive function in patients undergoing peritoneal dialysis?
Cross-Sectional (n=59)
No
Does dialysis adequacy correlate with cognitive function in patients undergoing peritoneal dialysis?
Effect estimate: r=-0.32
p-value: p=0.02
Relative overhydration in peritoneal dialysis patients is significantly correlated with worse performance on specific executive function tasks.
Higher RelOH was associated with executive dysfunction in PD; leaves open causality and requires prospective trials before practice change.
OBJECTIVE: Cognition of peritoneal dialysis patients is influenced by various factors including dialysis adequacy such as fractional urea clearance (Kt/V) and relative overhydration (RelOH). This study aimed to discover the potential contribution of dialysis adequacy to cognitive function in patients undergoing peritoneal dialysis. METHODS: Fifty-nine patients undergoing peritoneal dialysis were recruited. Demographic information, comorbidities, and clinical lab findings were retrospectively collected, and dialysis adequacy was determined by the Kt/V and RelOH calculation. Cognition and depression were measured with Digit Symbol Substitution Test, Hopkins Verbal Learning Test, Wechsler memory scale (spatial span), Wisconsin Card Sorting Test, and Beck's depression inventory. Partial correlation test was used to explore the correlation of dialysis adequacy with cognitive function. RESULTS: RelOH showed significant correlation with some of the Wisconsin Card Sorting test results. The categories achieved showed negative correlation (r=-0.32, p=0.02) and trials to complete first category showed positive correlation (r=0.31, p=0.02) with RelOH. Other tasks showed no significant correlation with RelOH. Kt/V. CONCLUSION: Our study demonstrates that peritoneal dialysis adequacy, measured by RelOH, seems to be significantly correlated with the occurrence of cognitive impairment. The outcome suggests that RelOH may have the potential to clarify the role of cognitive impairment in peritoneal dialysis patients.
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Shin et al. (2020) conducted a cross-sectional in End-stage renal disease undergoing peritoneal dialysis (n=59). Relative overhydration (RelOH) was evaluated on Correlation between RelOH and cognitive function (Wisconsin Card Sorting Test categories achieved) (r=-0.32, p=0.02). In patients undergoing peritoneal dialysis, higher relative overhydration (RelOH) was significantly correlated with lower executive function, including fewer categories achieved (r=-0.32, p=0.02).
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