Key result
Hydrogen-rich water reduces angina symptoms and improves atherogenic lipid profiles vs. placebo in unstable angina.
Why the study?
Hydrogen has potential antioxidative and anti-inflammatory effects that may benefit unstable angina, but its clinical effects require evaluation.
Does hydrogen-rich water improve angina symptoms and lipid levels in hospitalized patients with unstable angina?
RCT (n=40)
Does hydrogen-rich water improve angina symptoms and lipid levels in hospitalized patients with unstable angina?
Hydrogen-rich water may serve as a beneficial adjuvant therapy for reducing symptoms and improving lipid profiles in patients with unstable angina.
Answers are grounded in this paper and cite their sources.
May warrant further investigation but should not alter unstable angina management; leaves open clinical efficacy of hydrogen.
Oxidative stress and inflammation are closely related to atherosclerotic cardiovascular disease. It is established that hydrogen has significant protective effects on many diseases as a potential antioxidative and anti-inflammatory agent. The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo. An atherosclerosis model in vitro was constructed by ox-LDL-induced injury of human umbilical vein endothelial cells and in vitro testing indicated hydrogen inhibited ox-LDL-induced oxidative stress and inflammatory response by down-regulating LOX-1/NF-kB signaling pathway. Subsequently, the attenuating effect of hydrogen-rich water intake on unstable angina was further confirmed in clinic. Forty hospitalized subjects with unstable angina were enrolled and consumed either 1000–1200 mL/d hydrogen-rich water or the same amount of placebo pure water in addition to conventional drugs for three months. Clinical analysis showed hydrogen-rich water intake relieved angina symptoms in unstable angina patients. Serum analysis showed that hydrogen-rich water addition resulted in more effective reductions of total-cholesterol, low-density lipoprotein-cholesterol, and apolipoprotein B levels compared with conventional treatment. These results support that hydrogen as adjuvant treatment has a beneficial effect on unstable angina.
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Si et al. (2021) conducted an RCT in Unstable angina (n=40). Hydrogen-rich water vs. Placebo pure water was evaluated on Angina symptoms and lipid levels (total-cholesterol, LDL-C, apolipoprotein B). Hydrogen-rich water as an adjuvant treatment relieved angina symptoms and reduced total cholesterol, LDL-C, and apolipoprotein B levels compared with placebo in patients with unstable angina.
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