Unfortu-nately,littleisyetknownaboutthenega-tive effects of performing such tests, interms of, for example, unnecessary ex-posuretoradiationorfalse-positivere-sults, that may induce fear and anxietyinpatientsormayresultinacascadeofunnecessary further testing.Giventheseproblemsitischalleng-ing to learn how to change test order-ing performance effectively and bringit into line with existing evidence orguidelines on optimal testing. Manysuch attempts have been made withmixed results, showing that success-ful strategies require a well-balanced
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Verstappen et al. (2003) studied this question.