Key result
Fibromyalgia syndrome in women is linked to ~44% greater P wave dispersion versus healthy controls.
Why the study?
Impaired diastolic functions, P wave dispersion, and prolonged atrial conduction times are associated with increased incidence of atrial fibrillation, but their status in fibromyalgia syndrome patients was unclear.
Does fibromyalgia syndrome increase surrogate markers of atrial fibrillation risk (P wave dispersion and atrial conduction times) in female patients?
Case-Control (n=140)
Single-blind
Does fibromyalgia syndrome increase surrogate markers of atrial fibrillation risk (P wave dispersion and atrial conduction times) in female patients?
Answers are grounded in this paper and cite their sources.
Fibromyalgia syndrome is associated with impaired diastolic function, increased P wave dispersion, and prolonged atrial conduction times, suggesting an increased risk of developing atrial fibrillation.
INTRODUCTION: Atrial fibrillation (AF) is the leading cause of ischemic stroke and is one of the most common arrhythmias. Previous studies have shown that impaired diastolic functions, P wave dispersion (Pd), and prolonged atrial conduction times (ACT) are associated with increased incidence of atrial fibrillation (AF). The aim of this study was to evaluate diastolic functions, Pd, and ACT in fibromyalgia syndrome (FMS) patients to determine whether there is an increase in the risk of developing AF. METHODS: The study included a total of 140 female patients (70 FMS group, 70 healthy control group). Pd was evaluated using 12 lead electrocardiography (ECG), and diastolic functions and ACT with echocardiography. The ECG and echocardiographic evaluations were performed by different cardiologists blinded to the clinical information of the subjects. RESULTS: There was no difference between the two groups in laboratory and clinical parameters. Patients with FMS had significantly higher echocardiographic parameters of ACT known as left-sided intra-atrial (13.9 ± 5.9 vs. 8.1 ± 1.8, p < 0.001), right-sided intra-atrial (21.9 ± 8.2 vs. 10.4 ± 3.5, p < 0.001) and interatrial [40 (25-64) ms vs. 23 (14-27) ms p < 0.001] electromechanical interval (EMI) compared with the control group. Pd was significantly greater in the FMS group compared with the control group [46 (29-62) ms vs. 32 (25-37) ms, p < 0.001]. In the FMS group, there was no significant relationship of the echocardiographic parameters of ACT, Pmax and Pd with age, E/A ratio and deceleration time (DT); while all these five parameters were significantly correlated with left atrial dimension, isovolumetric relaxation time (IVRT), fibromyalgia impact questionnaire (FIQ) and visual analogue scale (VAS). There was a strong correlation between FIQ and VAS and echocardiographic parameters of ACT, Pmax and Pd. CONCLUSIONS: Impaired diastolic functions, an increase in Pd, and prolongation of ACT were observed in FMS. Current disorders are thought to be associated with an increased risk of AF in FMS. The risk of developing AF increases with the severity of FMS and clinical progression.
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Akkaya et al. (2020) conducted a case-control in Fibromyalgia syndrome (n=140). Fibromyalgia syndrome vs. Healthy controls was evaluated on P wave dispersion (Pd) (p=<0.001). Fibromyalgia syndrome in women was associated with significantly greater P wave dispersion (46 ms vs 32 ms, p<0.001) and prolonged atrial conduction times compared to healthy controls.
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