Purpose MMP-9 and IL-8 expression in the breast cancer tissue give a hint for patient progression. To know the prognostic value we are correlating MMP-9 and IL-8 with hormonal status and clinicopathological parameters can give a customise treatment for different patients. Materials and Methods This study included 46 breast cancer tissues without lymphnode involvement. HE and IHC staining were performed. Results There was a statistical significance between MMP-9 and IL-8 and some clinicopathological parameters. There was a statistical significance between MMP-9 and IL-8 and some clinicopathological parameters. No lymphnode involvement and Clinicopathological parameters shows significan with age, Tumor size, lymphvascular invasion, perineural invasion, tumor grade, tumor budding, PR expression, HER2 expression, and IL-8 expression. Conclusion The expression of MMP-9 and IL-8 in breast cancer tissue reveals there potential roles in tumor invasion and metastasis. Lower expression leads to more progression of the patients.
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Priyanka et al. (2025) studied this question.