Efficacy and safety of different revascularization strategies in patients with non-ST-segment elevation myocardial infarction with multivessel disease: a systematic review and network meta-analysis

Figure 1. PRISMA flow diagram

Figure 2. Risk of bias graph: Quality assessment using Newcastle-Ottawa Scale Tool

Figure 3. Network of eligible comparisons for primary efficacy and safety outcomes. A – All-cause mortality. B – Recurrent MI. The size of the node corresponds to the number of individual studies that studied the interventions. The directly compared interventions are linked with a line, the thickness of which corresponds to the number of studies that assessed the comparison SCR – staged complete revascularization, ICR – immediate complete revascularization, COR – culprit-only revascularization, MV-PCI – Multi-vessel PCI, MI – myocardial infarction.

Figure 4. Network meta-analysis of primary efficacy (all-cause mortality) and safety (recurrent MI) outcomes. Interventions are ordered by ranking for all-cause mortality. Results are the OR (95% CI) from the network meta-analysis between the column-defining intervention and row-defining intervention. Comparisons should be read from left to right. Numbers in bold represent statistically significant results SCR – staged complete revascularization, ICR – immediate complete revascularization, COR – culprit-only revascularization, MV-PCI – multi-vessel PCI, MI – myocardial infarction, OR – odds ratio.

Figure 5. Networks map of treatment comparisons for each outcome

Figure 6. A – Network estimated odd ratios (95% confidence intervals) of treatment options for all-cause mortality. B – Network estimated odd ratios (95% confidence intervals) of treatment options for recurrent MI. C – Network estimated odd ratios (95% confidence intervals) of treatment options for MACEs. D – Network estimated odd ratios (95% confidence intervals) of treatment options for cardiac mortality. E – Network estimated odd ratios (95% confidence intervals) of treatment options for repeat revascularization SCR – staged complete revascularization, ICR – immediate complete revascularization, COR – culprit-only revascularization, MV-PCI – multi-vessel PCI, MACEs – major adverse cardiac and cardiovascular events, MI – myocardial infarction. *Treatments are ordered by SUCRA rank. Comparisons between treatments should be read from column to row for each outcome (row treatment is reference)