Palmitate and oleate oxidation in isolated mitochondria from alloxan diabetic rat liver were shown to be elevated two or threefold over normal. These increases were accompanied by enlargement of mitochondria as observed by electron microscopy. These metabolic and structural changes were reversed by treating the diabetic rat with insulin. The activities of citric acid cycle enzymes in MT were unchanged in the diabetic state. It is suggested that insulin regulates LCFA oxidation in the liver by an effect on MT structure and function.
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Harano et al. (1969) studied this question.
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