Most drugs are delivered as crystalline solids, but some widely used pharmaceutical ingredients cannot be crystallized at ambient conditions: propofol, one of the most widely used anesthetic agents in the world is a liquid. Here we stabilize propofol in a crystalline phase by cocrystallization, and we thoroughly characterize the structural and thermodynamic properties of the new materials. Ternary solubility diagrams of a liquid pharmaceutical ingredient cocrystallized with a solid coformer are presented and analyzed for the first time. It is shown that, when equilibrated with the solid cocrsytal, the concentration of propofol in water is kept constant in a wide range of starting compositions.
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Bacchi et al. (2016) studied this question.
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