Aspergillosis in a Healthy Host

This case report describes an unusual occurrence of invasive aspergillosis in a previously healthy, nonimmunocompromised woman. Repeatedly positive sputum cultures were misinterpreted as not significant, and the diagnosis was not made until after the patient died. Serial sputum cultures positive for Aspergillus in a patient with pneumonia who is not responding to treatment should prompt the clinician to consider invasive aspergillosis.