Spinal Meningeal Carcinomatosis in Small-Cell Carcinoma of the Lung

Brief Reports1 April 1978Spinal Meningeal Carcinomatosis in Small-Cell Carcinoma of the LungHARMAR D. BRERETON, M.D., JOSEPH F. O'DONNELL, M.D., C. HARRY KENT, M.D., MARY MATTHEWS, M.D., N. REED DUNNICK, M.D., RALPH E. JOHNSON, M.D.HARMAR D. BRERETON, M.D.Search for more papers by this author, JOSEPH F. O'DONNELL, M.D.Search for more papers by this author, C. HARRY KENT, M.D.Search for more papers by this author, MARY MATTHEWS, M.D.Search for more papers by this author, N. REED DUNNICK, M.D.Search for more papers by this author, RALPH E. JOHNSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-517 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMeningeal carcinomatosis is an uncommon but well-documented event in the course of various neoplasms (1). However, the accurate diagnosis or anticipation of meningeal carcinomatosis, unlike meningeal leukemia(2), has made no difference in patient survival. Further, the frequency with which meningeal carcinomatosis occurs in most carcinomas is sufficiently obscure, and most likely very low, that prophylactic treatment of this sanctuary site would not be warranted. However, with improved treatment and prolonged survival for some patients with small-cell lung cancer (3), we have encountered a 9% incidence of spinal meningeal carcinomatosis in this disease.Fifty-eight consecutive patients with small-cell carcinoma of...References1. OLSON M, CHERNIK N, and POSNER J: Infiltration of the leptomeninges by systemic cancer. Arch Neurol 30:122-137, 1974 CrossrefMedlineGoogle Scholar2. AUR R, HUSTU H, VERYOSA M, WOOD A, and SIMONE J: Comparison of two methods of preventing central nervous system leukemia. Blood 42:349-357, 1973 CrossrefMedlineGoogle Scholar3. BRERETON H, KENT C, and JOHNSON R: Chemotherapy and radiotherapy for small cell lung cancer (abstract). Proc Am Soc Clin Oncol 18:275, 1977 Google Scholar4. JACKSON D, COOPER M, RICHARDS F, FERREE C, MUSS H, WHITE D, and SPURR C: Prophylactic cranial irradiation in small cell carcinoma of the lung. JAMA 237:2730-2733, 1977 CrossrefMedlineGoogle Scholar5. HOLOYE P, SAMUELS M, LANZOTTI V, SMITH T, and BARKLEY H: Combination chemotherapy and radiation therapy for small cell carcinoma. JAMA 237:1221-1224, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARMAR D. BRERETON, M.D.; JOSEPH F. O'DONNELL, M.D.; C. HARRY KENT, M.D.; MARY MATTHEWS, M.D.; N. REED DUNNICK, M.D.; RALPH E. JOHNSON, M.D.Affiliations: National Cancer Institute Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTeniposide for meningeal carcinomatosis of small cell lung cancerTreatment of central nervous system metastases from small cell lung cancer with chemotherapyChemotherapy for central nervous system metastases from small cell lung cancer. A reviewBilateral parotid gland metastasis as the initial presentation of a small cell lung carcinomaSerial lumbar and ventricle cerebrospinal fluid lactate dehydrogenase activities in patients with leptomeningeal metastases from solid and haematological tumours.Diagnosis of leptomeningeal metastasisSimultaneous leptomeningeal and intramedullary spinal metastases in small cell lung carcinomaDiagnostic Procedures in the Detection of CNS Metastases from Small Cell Lung CancerSpinal cord metastasis in small cell carcinoma of the lungPatterns of Failure in Small Cell Lung Cancer: Implications for TherapyCarcinomatous Meningitis in Small Cell Lung CancerLong term survivors with leptomeningeal tumor involvementCerebrospinal fluid flow abnormalities in patients with neoplastic meningitisMeningeal carcinomatosis in small cell carcinoma of the lungLeptomeningeal spread of breast cancer: Report of case and review of the literatureMeningeal carcinomatosis in small cell carcinoma of the lungLeptomeningeal carcinomatosis in small cell carcinoma of the lungSmall Cell Bronchogenic Carcinoma: A Review of Therapeutic ResultsChemotherapy versus chemoimmunotherapy for small-cell undifferentiated carcinoma of the lungThe Effect of Lithium Carbonate Administration in Patients with Advanced Small Cell Bronchogenic Carcinoma Receiving Combination Chemotherapy and RadiotherapyCentral Nervous System Metastases in Small Cell Carcinoma of the Lung — A ReviewCNS metastases in small cell bronchogenic carcinoma.Increasing frequency and changing pattern with lengthening survivalImmunotherapy of lung cancer“Total” Therapy for Small Cell Carcinoma of the Lung 1 April 1978Volume 88, Issue 4Page: 517-519KeywordsCancer treatmentCarcinomatosisLung and intrathoracic tumorsRespiratory system procedures ePublished: 1 December 2008 Issue Published: 1 April 1978 PDF downloadLoading ...