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The diagnosis of dengue disease, caused by the dengue virus (DENV) (a flavivirus), often requires serologic testing during acute and early convalescent phases of the disease.Some symptoms of DENV infection, such as nonspecific fever, are similar to those caused by infection with SARS-CoV-2, the virus that causes COVID-19.In studies with few COVID-19 cases, positive DENV immunoglobulin M (IgM) results were reported with various serologic tests, indicating possible cross-reactivity in these tests for DENV and SARS-CoV-2 infections (1,2).DENV antibodies can cross-react with other flaviviruses, including Zika virus.To assess the potential cross-reactivity of SARS-CoV-2, DENV, and Zika virus IgM antibodies, serum specimens from 97 patients from Puerto Rico and 12 U.S.based patients with confirmed COVID-19 were tested using the DENV Detect IgM Capture enzyme-linked immunosorbent assay (ELISA) (InBios International).*In addition, 122 serum specimens from patients with confirmed dengue and 121 from patients with confirmed Zika virus disease (all from Puerto Rico) were tested using the SARS-CoV-2 pan-Ig Spike Protein ELISA (CDC).† Results obtained for DENV, Zika virus IgM, and SARS-CoV-2 antibodies indicated 98% test specificity and minimal levels of cross-reactivity between the two flaviviruses and SARS-CoV-2.These findings indicate that diagnoses of dengue or Zika virus diseases with the serological assays described in this report are not affected by COVID-19, nor do dengue or Zika virus diseases interfere with the diagnosis of COVID-19.Persons infected with SARS-CoV-2 can be asymptomatic or experience a range of illnesses from mild fever to lifethreatening respiratory disease.In mildly symptomatic patients with fever, COVID-19 might be confused with other diseases that have similar symptoms, including dengue and Zika virus diseases.Dengue, caused by four antigenically distinct dengue virus serotypes (DENV-1-4) transmitted by Aedes spp.mosquitoes, is usually a mild febrile illness but might evolve into severe dengue disease resulting in life-threatening conditions, such as dengue hemorrhagic fever and dengue shock syndrome.Dengue disease is a major public health problem throughout tropical and subtropical regions, causing approximately * http://inbios.com/wp-content/uploads/
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Muñoz‐Jordán et al. (2022) studied this question.
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