Fatal aplastic anemia associated with allopurinol therapy

Fatal Aplastic Anemia Associated With Allopurinol TherapyAllopurinol (Zyloprim) is a drug widely used for the treatment of hyperuricemia.Although fatal agranulocytosis has been reported, significant hematologic toxicity is uncommon and has been reported previously only in patients receiving other drugs with a known myelosuppressive potential [l-51.We have observed a patient with severe myelosuppression on two separate occasions following the administration of allopurinol who died with aplastic anemia.A 63-year-old white grocer was hospitalized for a grand ma1 seizure.His blood pressure was 230/120 mmHg.Laboratory studies revealed a serum creatinine of 4